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Overhead view of finished meatloaf sliced in white baking dish.
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5 from 2 votes

Southern Meatloaf Recipe

Easy Southern Meatloaf Recipe is classic comfort food with a southern-style twist. It’s simply made with ground beef, ground pork, white bread, ketchup based sauce, and more.
Prep Time15 minutes
Cook Time1 hour
Total Time1 hour 15 minutes
Course: Main Course
Cuisine: American
Keyword: meatloaf
Servings: 16
Calories: 269kcal

Ingredients

  • 1 cup milk
  • 6 slices sandwich bread
  • 1 pound ground beef
  • 1 pound ground pork
  • 1 cup grated Parmesan cheese
  • ¾ cup green bell pepper, diced
  • cup onion, diced
  • ¼ teaspoon seasoned salt
  • ¾ teaspoon salt
  • ½ teaspoon ground black pepper
  • cup fresh Italian parsley, chopped
  • 4 large eggs, beaten
  • 1 ½ cups ketchup
  • cup brown sugar
  • 1 teaspoon dry mustard powder
  • ¼ teaspoon hot sauce

Instructions

  • Begin the recipe by preheating the oven to 350 degrees F. Using a large mixing bowl add the 6 slices of bread and 1 cup milk. Allow time for the milk to soak into the bread about 2 to 3 minutes.
  • To the same bowl, add the 1 pound ground beef, 1 pound ground pork, 1 cup Parmesan cheese, ⅓ cup onion, ¾ cup green bell pepper, ⅓ cup chopped Italian parsley, ¼ teaspoon seasoned salt, ¾ teaspoon salt, and ½ teaspoon ground black pepper. Stir to combine. 
  • Lightly beat the 4 large eggs and add them to the bowl with the other ingredients. Using clean or gloved hands, mix the ingredients until well combined. The meat mixture should be able to form into a loaf. 
  • Remove the meatloaf mixture from the bowl and add it to a baking pan, broiler pan, or sheet pan (lined with aluminum foil). Use your hands to form the mixture into a loaf shape. Set aside. 
  • Using a small bowl, whisk together the 1 ½ cups ketchup, ⅓ cup brown sugar, 1 teaspoon mustard, and ¼ teaspoon hot sauce until combined. Spread about ⅓ of the sauce evenly on top of the uncooked meatloaf. Place into the preheated oven to bake for 45 minutes. 
  • Carefully remove the meatloaf from the oven and evenly spread another layer, about half of the sauce that is left, over the top of the cooked meatloaf. Place the meatloaf back into the oven and continue baking for about 15 to 20 minutes, until the internal temperature reaches 160 degrees F. 
  • Carefully remove the fully cooked meatloaf from the oven and serve warm with the remaining sauce. Try pairing it with mashed potatoes for a complete and comforting family dinner. Enjoy!

Notes

  • Allow the meatloaf time to rest for about 10 to 15 minutes before slicing to serve for the juiciest meatloaf. 
  • Be sure to use a meat thermometer (instant-read thermometer) to check the internal temperature of the meatloaf before removing it from the oven to serve. The internal temperature should reach 160-165 degrees F. 
  • After cooking the meatloaf for 45 minutes, carefully drain off the fat before adding the second layer of sauce. I prefer to use a second pan and simply transfer the meatloaf to the clean pan before topping it with the sauce. 
  • Cook the meatloaf in a 9x13-inch baking dish (casserole pan), a large sheet pan (baking sheet) lined with aluminum foil for easy cleanup, a loaf pan, or a broiler pan with a rack to easily allow the fat to drain away from the meatloaf while cooking. 
  • Do not cover the meatloaf with aluminum foil while baking in the oven. This will steam the meatloaf instead of it browning and caramelizing. 

Nutrition

Calories: 269kcal | Carbohydrates: 18g | Protein: 15g | Fat: 16g | Saturated Fat: 6g | Polyunsaturated Fat: 1g | Monounsaturated Fat: 6g | Trans Fat: 0.4g | Cholesterol: 94mg | Sodium: 566mg | Potassium: 316mg | Fiber: 1g | Sugar: 11g | Vitamin A: 395IU | Vitamin C: 9mg | Calcium: 121mg | Iron: 2mg